3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one
protosappanin A
CAS: 102036-28-2
Molecular Formula: C15H12O5
3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one - Names and Identifiers
3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one - Physico-chemical Properties
| Molecular Formula | C15H12O5 |
| Molar Mass | 272.25 |
| Density | 1.476±0.06 g/cm3(Predicted) |
| Melting Point | 254-255 °C |
| Boling Point | 613.1±55.0 °C(Predicted) |
| pKa | 9.01±0.20(Predicted) |
| Storage Condition | 2-8℃ |
3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one - Reference Information
| biological activity | Protosappanin A (PTA), an immune preparation, it is a major biphenyl compound isolated from Caesalpinia sappan L, which inhibits the JAK2/STAT3-dependent inflammatory pathway by down-regulating the phosphorylation of JAK2 and STAT3. |
| Cell Line: | Murine BV2 microglial cell line. |
| Concentration: | 12.5, 25, 50 μM. |
| Incubation Time: | 24 hours. |
| Result: | Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells. Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells. Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells. |
Last Update：2024-04-09 20:49:11
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